New Bestcilia publication: PCD and female reproduction
A notable publication has recently been issued by researchers involved in Bestcilia WP1, supervised by prof. Heymut Omran (University Hospital, Munster, Germany), who also coordinates the consortium as a whole. The article investigates the ciliary function of human fallopian tubes and lays the groundwork for research on the possible implications of PCD for fertility and reproduction.
Many female PCD sufferers experience subfertility and other related gestational problems, such as e.g. ectopic pregnancies. This correlation lies at the center of the present study, which aimed to discover the composition and function of cilia in human fallopian tubes. For this purpose, ciliary motility, transport and motor protein composition of fallopian tubes were analyzed in material obtained during caesarean sections of 5 healthy female patients. The results of the study were compared to information on conception and childbirth derived from a retrospective analysis of the PCD clinical database.
The study revealed that cilia located in fallopian tubes have identical motor protein composition as in the respiratory tract and their coordinated movement results in the flow of fluids towards the uterine cavity. When reviewing the PCD clinical database, authors have found 9 cases of healthy pregnancies and childbirths following a spontaneous conception in women with severe PCD; this finding suggests that cilia motility is not highly relevant for ovum transport. Subsequent studies will verify whether the dysfunction of respiratory cilia motility resembles the defects of fallopian tubes cilia in PCD sufferers. In general, the present study will also contribute to a better understanding of the role which cilia play in the flow of fluids relevant for female reproduction.
Full article is available here.